Langerhans cells were increased in number in the skin of fracture mice and CRPS patients, and those increases in mice were reduced in neuropeptide signaling-deficient animals.
Although the frequency and absolute number of B220+ cells from Rag2 KI mice were reduced in the bone marrow, spleen, and inguinal lymph nodes compared with Rag2 WT mice, B cells were not absent (Supplementary Fig. S4).
HPLC revealed that GABA levels in GAD65−/− mice were reduced in the brain (76.7% of WT) and spinal cord (68.5% of WT).
The blood glucose levels of the glucose loaded mice were reduced significantly when administered at doses of 50, 100, 200 and 400 mg/kg body weight of EEPHL.
The elevated monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α) levels in obese mice were reduced in S. alata treatment.
Essentially, the mean onset and percentage protection against convulsion in C. edulis extract-treated mice were reduced by flumazenil and naloxone.
Histologic examination of the CNS from MOG-immunized mice revealed extensive inflammatory lesions in the cPLA2alpha+/- mice, whereas the lesions in cPLA2alpha-/ mice were reduced greatly or completely absent.
Blood sugar levels of the tested mice were reduced significantly by 48.8, 51.5, 54.1, 58.2 % (p < 0.05) compared to control mice with the increasing dosage of the extract such as 50, 100, 200 and 400 mg/kg of body weight respectively.
The blood glucose levels of the mice were reduced significantly when administered total extract and petroleum ether, chloroform, ethyl acetate and aqueous after 5 h, where the percent of lowering blood glucose levels were 47.49, 47.79, 50.04, 49.80 and 46.36%, respectively, compared with that of metformin (55.45%).
