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CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories.
Indeed, when submitted to the variable starting point procedure, bigenic-Dox mice were profoundly impaired in learning the platform location (Figure 6A; group effect: F1,10 = 16.33, p<0.002; group×time interaction: F8,80 = 2.80, p<0.008).
Myo15 ΔN/ΔN mice were profoundly deaf at all frequencies tested.
These results indicated that Bcl2−/− mice were profoundly deaf at 3 weeks of age, soon after auditory development is complete.
A residual startle response in almost all mice tested indicated that neither Scn8a Clth /+ or Scn8a Clth /Scn8a Clth mice were profoundly deaf.
As a4 KO mice were profoundly deaf and displayed enlarged endolymphatic fluid compartments mirroring the alterations in pendrin KO mice, we propose that pendrin and the proton pump co-operate in endolymph homeostasis.
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Here, we show that PKCgamma-/ mice are profoundly impaired in vestibulo-ocular reflex (VOR) motor learning.
Fig. 1D demonstrates that the endurance of the knockin mice is profoundly diminished, relative to their wild-type counterparts.
The demyelination in the lumbar spinal cords of EAE mice was profoundly ameliorated by berberine treatment when compared with PBS treatment (P<0.01, Fig. 2).
Strikingly, 4 hours after oligodendrocyte ablation, the pattern of expression of Sema3A and Netrin-1 throughout the cerebella of MBP-TK treated mice was profoundly altered as compared to treated WT littermates.
Using MCMV infection of LMP7−/− mice and ex vivo CD8+ T cell assays for number and function, we found that the M45-specific CD8+ T cell response to MCMV that is immunodominant in C57BL/6 mice is profoundly affected by loss of immunoproteasomes.
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