Genetically engineered mice were originally generated to delineate the role of a specific gene product in behavioral or neuroendocrine phenotypes, rather than to produce classic animal models of depression.
Briefly, Ogg1 null mice were originally created in 1999 [14].
The Atm-/ mice were originally generated by Dr. C. Barlow.
The C57BL/6J mice were originally purchased from Charles River Japan, Inc. (Yokohama, Japan), and the ICR mice were originally obtained from Japan CLEA Japan Inc. (Yokohama, Japan).
Myh null and Ogg1 null mice were originally crossed to generate Myh+/− Ogg1+/− mice [16], [19].
CBA.Ca (CBA; H2k) and C57BL/10 (B10; H2b) mice were originally purchased from Harlan Olac.
Cra1/+ mice were originally reported to exhibit late onset, progressive degeneration of motor neurons [9].
C57BL/6 (B6) mice were originally obtained from Bomholt gård (Ry, Denmark).
TRAP overexpressing mice were originally generated in order to study the skeletal phenotype and bone turnover [10].
Pin1 null mice were originally generated by Fujimori, and the Pin1 deletion was transferred into an isogenic C57BL/6J background by Jackson Laboratory.
Cln6nclf spontaneous mutant mice were originally purchased from The Jackson Laboratory, and were subsequently maintained as a breeding colony on the C57Bl6/J background, at Massachusetts General Hospital.
