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Despite high RTB-specific serum antibody titers, groups of RTB immunized mice were only partially immune to ricin challenge.
According to this scenario, the 'CB3' receptor is only partially responsible for newborn milk suckling since the cannabinoid CB1 knockout mice were only partially affected by the antagonist.
Interestingly, the Cox1 null mice generally had no identifiable gastrointestinal abnormality, despite the fact that gastric PGE2 levels in null mice were only 1% of the levels observed in wild type mice (Langenbach et al., 1995).
The other two groups of mice were only treated with L435-3 or mock control.
Control FoxP3GFP mice were only given 100 µl 1×PBS injection.
For the Dox alone group, the mice were only treated with Dox (2 mg/kg body weight) by weekly intraperitoneal injection over 4 weeks.
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Until recently, quantification of myocardial infarct size in mice was only possible by use of post-mortem histological analysis.
After 72 hours, the induction of hepatic collagen alpha1(I) and alpha2(I) messenger RNA (mRNA) levels in Smad3 knockout mice was only 42% and 64%, respectively, of the levels induced in wild-type mice.
The life span of the mice was only about 18 months, while the rats typically lived twice as long.
Further, the lifespan of mdx mice is only moderately reduced [2], [3].
In addition, the frequency of viable Alkbh1+/− mice was only 60% of the expected rate (Fig. 3A).
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