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The bi-maternal mice were noticeably smaller and about two-thirds the weight of the normally bred animals.
3 weeks after birth, linc Pint −/− mice were noticeably smaller than wild-type littermates.
In several instances, mice were noticeably inactive during the place-preference tests.
The pancreata of neonatal ABKO mice were noticeably smaller than those of controls at P7 (Fig. 2A,B) but not at P30 (data not shown).
Ercc1− / + and Ercc1 Δ/ + do not differ from wild-type mice and show normal aging [ 17, 65], instead Ercc1 Δ/ − mice were noticeably smaller and showed reduced body weight compared to wild-type littermates (Fig. 1a, c).
LLKB1KO mice were noticeably smaller than either Lkb1 fl/fl or wild-type mice and had significantly lower body weight from 4 days of age, and rapidly began to lose weight from around 15 days of age.
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The social responsiveness of adolescent mice was noticeably variable across adolescent development (main effect of age, F [4,260] = 2.3, P = 0.06).
In contrast, alpha-syn immunolabeling in tg mice was noticeably increased, more diffuse in nature, and immunopositive cell bodies, dendrites and other elements in the neuropil were observed in many regions.
The silver impregnation of the P. murina in the lungs of the treated mice was noticeably diminished in the GMS (Grocott's methenamine silver) stained slides (Panels d-l) while those from the untreated mice exhibited strong silver staining and typical cup-shaped cyst morphology (Panels a c).
These findings show two interesting trends: i) islets from single mice showed a strong correlation between [Ca2+]i and insulin secretion patterns (R2 = 0.98; p<0.0001) and, importantly, ii) the oscillation periods were noticeably different from mouse to mouse.
Lung metastases were noticeably reduced in mice treated by GC-HIFU compared with all other groups.
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