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These mice were nearly twice as heavy as the control mice, and their body composition differed by a significant increase in bone density and a small decrease in percentage of body fat.
Levels in old mice were nearly 15-fold higher than young (Fig. 1a).
The period lengths of C57BL/6J, AMPKα1+/+ and AMPKα2+/+ mice were nearly identical (Figure S1).
Furthermore, the mean water content of the feces on day 8 was no greater than that of uninfected control mice, while feces from WT infected mice were nearly 80% water (Figure 3B).
In eight out of nine cases, differences between antibiotic and sham treated mice were nearly identical to differences between germ-free and conventional mice strongly suggesting that the altered gene expression profile is a consequence of the highly reduced microbial stimulation of the colonic IECs.
The increases in lipogenic gene expression observed in WT-PM mice were nearly normal in CCR2-PM mice, with the exception of DGAT2.
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The severe deficiency of these cells observed in the Id1-/ mice was nearly completely corrected in the Id1-/ p21-/ mice.
Mean nose-anus length of CXCL14−/− mice was nearly identical to that of CXCL14+/− mice (Figure 2E).
Besides, the new cells surviving more than 1 month after birth in the granule cell layer of adult mice are nearly 90% neurons (reviewed by [58]).
Further, although phosphorylation of MKK6 of MHC class II+ dermal DCs in the skin sheets from MKK6 siRNA-treated mice was nearly undetectable, there was phosphorylation in the sheets from control siRNA-treated mice (Figure 6D).
CD treatment also diminished accumulation of gangliosides, such that GM2 and GM3 storage in the neocortex of treated Npc1−/− mice was nearly absent compared to readily detectable storage in untreated Npc1−/− mice (Fig. 3B; GM3 not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com