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Atopy and spontaneous peritoneal eosinophilia, characteristic of Lyn−/− mice, were lost in young Lyn−/−STAT6−/− mice; however, autoimmune disease was markedly exacerbated.
Two mice were lost to follow-up.
During the DCP gavaging period three mice were lost because of gavaging trauma: one control and two from the 63 mg/kg/ day group.
Parakeratotic scales, which are negative for K10 but express high levels of p63 in wild-type mice, were lost when S was depleted.
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Thus, although Gnat1−/− Gnat2cpfl3/cpfl3 mice retain an ERG to a very high intensity flash, responses at moderate light levels (which are a feature of TKO mice) are lost.
Unfortunately this strain of mice was lost by the time of the initial publication [32] so that we cannot directly compare the levels of MYC in these mice to those of the Lo-MYC mice.
This unexpected protection against PH-induced liver injury was systematically observed in TRα1/TRβ double KO mice and in MMI treated mice, being lost after administration of T4 in the latter case.
Interestingly, the normal positive feedback response of AVPV kisspeptin neurons to estrogen observed in WT mice was lost in hpg females, suggesting that exposure to reproductive hormones during development may contribute to the establishment of the ovulatory gonadotropin surge mechanism.
This is consistent with the observation that protection against DSS colitis in IL-25−/− mice was lost by the third cycle of DSS treatment.
One approach will be to alter the expression (e.g. by interference RNA) of a suspected gene in cell lines with 11q23 translocations, and examine whether the capacity of the cell lines to induce leukaemia in mice is lost.
When zfp57 expression in mice was lost only in the zygote (zfp57 −/− offspring from zfp57 +/− mothers), partial hypomethylation in some embryonic maternally methylated and some paternally methylated DMRs and peri- and neonatal lethality was observed in the majority of homozygous offspring.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com