He warned that only 20% of the mice were long-term survivors so the vaccine would need further development.
Experimentation was performed under dim red light (<0.25 µW/cm2, >650 nm), and mice were long-term dark adapted (>12 hr) prior to recording.
Mice were long-term dark adapted (>12 hr) and prepared for electroretinography under dim red light (<−0.6 log10 cd/m2 >650 nm).
In this study, the C57BL/6J mouse model was long term high-fat (HF) or low-fat (LF) diet fed, in order to analyze molecular mechanisms responsible for the hepatic damage progression.
The Berlin Muscle Mouse population had been long term selected for high body weight and high muscle mass to reflect the selective mechanisms in livestock breeding.
Strategic thinking is long term.
These results were further evaluated in vivo, in which 90% of the mice with intracranial tumours were long-term survivors (>100 days) after treatment with TMZ and CRAd-S-pk7 (P<0.01).
Very recently, using a multicolor sorting strategy to purify this subset from CB and subsequently transplanting them into NOG mice, Weissman's lab demonstrated that up to 10% of these cells were long-term SCID-mouse repopulating cells (LT-SRCs).
Also, 24 hours following a single intra-peritoneal 2 mg/kg ethanol dose to C57BL/6J mice, there is long-term potentiation of GABA synaptic transmission at Ventral Tegmental Area dopaminergic neurons, via a cAMP-PKA-dependent mechanism [ 18].
Adams cautions, however, that there could be difficulty scaling the technique up from mice to humans, and there could be long-term tissue damage from the radiation.
In agreement with other studies using mice, these observations indicate that there is long-term persistence of plasmid DNA [ 10], and expression of the transgene luciferase [ 10] and rtTA [ 23] encoded by the autoregulatory plasmid.
