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Reduced oligodendrogenesis in Myrf ICKO mice were likely a result of a failure of OPCs to fully differentiate/mature and subsequently being more vulnerable to apoptosis31.
A priori, we predicted pinyon mice were likely amplification agents since they co-occur with deer mice in relatively high densities in the Great Basin and they are potential reservoirs for SNV (S. St. Jeor, unpublished).
Such effects of intervention on the FGF receptor in diabetic mice were likely transcription-dependent).
Shimizugawa et al. [ 9] and Ando et al. [ 30] suggest that the low plasma lipid levels (especially TAGs) observed in ANGPTL3-deficient mice were likely caused by increased VLDL TAG clearance via induced LPL activity rather than decreased VLDL secretion.
Low levels of EGFP and WT eNOS expression in kidney and liver of BM-transplanted eNOS−/− mice were likely due to residual circulating EGFP+ donor-derived blood cells in these organs.
House mice were likely introduced to this island by sealers or whalers in the 19th century and are the only terrestrial mammals living on it (Holdgate, 1965; Gray et al., 2014).
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Thus, the CNS effects that were observed following systemic GDF11 treatment in old mice are likely indirect, with brain endothelial cells being a potential GDF11 cellular target.
Rather, the obesity in male Mt3-null mice was likely the result of decreased metabolic rates, as indicated by lower oxygen consumption and carbon dioxide production.
"On Juan de Nova, intrinsic factors such as predation by cats, and to a lesser extent resource competition with mice, are likely to have created selective pressure limiting the body-size of rats," suggest the authors.
So Halpern thinks the behavior-altering results his team observed in mice are likely to apply to humans, although further study will be needed to confirm these findings in a single human subject.
Here we show that enhanced retention of exosomes, compared to liposomes, in the circulation of mice is likely due to CD47-mediated protection of exosomes from phagocytosis by monocytes and macrophages.
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