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Among sex-matched mutants, B6 mice had lower cholesterol levels than 129 mice (p<0.001, males and females); F1 mice were intermediate (Figure 3b).
Pathology scores for perinatally treated mice were intermediate between OVA-challenged controls and lifelong vancomycin-treated animals (Fig. 1D).
Levels of hepatic TG in heterozygous mice were intermediate between those of wild-type and homozygous KI animals.
Serum creatinine levels in +/- mice were intermediate between the two homozygous groups, but did not differ statistically from either of the other two genotypes at any time point.
Heterozygous mice were intermediate and not significantly different from either parental genotyping suggesting an additive inheritance pattern with the A allele conferring increasing exercise capacity.
The length and branching data and the Sholl profiles for heterozygous mice were intermediate between those of wild type and homozygous, suggesting a gene dosage effect.
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Consequently, the number of calbindin+ve neurons in Amh -/- adult male mice was intermediate between Amh +/+ males and Amh +/+ females.
Importantly, these declines appear to reflect the disease state of each model, with mildly-affected mdx mice being intermediate to healthy w.t.
In summary, the present study clearly demonstrates that non-invasive imaging of biomarkers accurately reflects the disease state (ie., mdx mice are intermediate in disease severity to healthy wild-type mice and severely-affected udx mice).
Production of IL-6 in DSS/6-TG 40 treated mice was intermediate between that of DSS/PBS- and DSS/6-TG 20 treated mice, the difference was not, however, significant.
The expression of Akt2 variant 2 (but not variant 1) mRNA in quadriceps muscle in heterozygous mice was intermediate between wild-type and homozygous staggerer (sg/sg) mice (Fig. 3o, p).
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