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First, these mice were extensively phenotyped for aggression and anxiety in comparison to BALB/cByJ controls.
Thus, cells from embryo/fetus of Atg7−/− mice and certain cell/tissue-specific Atg7-knockout postnatal mice were extensively employed in the quest for understanding the mechanisms underlying the pleiotropic effects of ATG7 in development, physiology, and pathology (Table 1).
Between the P30 and P75 testing, the mice were extensively handled and subjected to frequent behavioral testing, but between P75 and P170 handling was intentionally kept to a minimum.
After the acclimation period and before the training and testing the mice were extensively handled (7 10 times for 1 2 min on different days).
In contrast, the neonatal skin of TRF2 Δ/Δ -K5-Cre, TRF2 Δ/Δ -K5-Cre 53BP1 −/−, and TRF2 Δ/Δ -K5-Cre p53 −/− mice were extensively undeveloped, consisting of rare small regions that were largely necrotic (Fig 4A).
Although none of the nTg or the M20 Tg mice were extensively analyzed for behavioral changes, the presence of αS pathological inclusions was not associated with any overt behavioral abnormalities.
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Among them, APP23 and APPswe/PS1deltaE9 (deltaE9) mice are extensively studied.
C57BL/6 mice are extensively used as the background of genetically modified animals in the field of bone research, and therefore we used the C57BL/6 mouse unilateral tibia/fibula axial loading model [12,27,29].
We conclude that the distal gut of humans and mice is extensively equipped with sensors for products of fat and protein digestion, and that these associate with specific signalling pathways, two of which have been shown here.
In vivo xenograph tumor models developed by subcutaneous implantation of glioma cell lines in mice are extensively used [ 6, 7] to test therapeutical approaches that target angiogenesis, local invasion and secretion of immune suppressive molecules.
The evaluation of the usability of this system in different mice models of arthritis is important taking into consideration that mice are extensively used in the study of the disease, both in the pathogenesis of the disease and search for therapeutic targets and molecules, and also that mice are the preferred animals for genetic modification to study biology and disease [ 17].
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