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We found that BrdU-labeled cells in the control mice were exclusively located in the lower parts of the crypts in the 1 h group (Fig. 5E, left panel) and only few cells had migrated towards the villi in the 24 h group (Fig. 5E, right panel).
The mice were exclusively male and the offspring of the same founder animals.
First, most (four of six) spontaneous papillary carcinomas of BALB/cJ mice (Fig. 1) and all (four of four) papillary carcinomas with a pseudostratified epithelium in SV40-TAg-transgenic mice were exclusively composed of cells with a luminal phenotype (simple carcinomas).
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Consequently, the reduction in body weight gain observed in Qβ-GIP-vaccinated mice was exclusively due to decreased fat accumulation.
(ii) The earliest single pAkt+ (Pten−) hyperplastic cells in the prostates of young targeted Pten knockout mice are exclusively present in the luminal epithelial cell layer.
The observations that mammary neoplasms of mice transgenic for H-Ras, Myc, Neu, Notch4 and SV40-Tag, and that papillary carcinomas of BALB/cJ mice are exclusively composed of cells with a luminal phenotype, are consistent with the hypothesis that these neoplasms arise from a cell committed to the luminal lineage.
To determine whether the deletion of JAM-C in the JAM-C SC KO mice was exclusively limited to SCs, the expression of JAM-C in other cell types known to express this molecule (i.e., endothelial and epithelial cells) was investigated by immunofluorescent staining and analysis by confocal microscopy of whole-mount cremaster muscles.
Mouse macrophages were exclusively used for the experiments in Figures 1 through 3, since high cell numbers were needed for these experiments in order to obtain adequate numbers of nuclei.
Moreover, post-sigh apneas in mice were observed exclusively during slow-wave sleep (SWS) while spontaneous apneas were seen in both SWS and rapid eye movement (REM) sleep.
Because of the high lethality, dKO mice were obtained exclusively by breeding double heterozygous mice to avoid any selection of potential modifiers.
CoQ9 and CoQ10 in lipid extracts prepared from the liver of un-supplemented mice were present exclusively in the oxidized quinone state.
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