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No significant difference, however, was observed between transgenic mice and wild-type littermates, indicating that the number of neuronal progenitor cells and the rate of BrdU incorporation into progenitor cells in transgenic mice were essentially normal.
The spleen bacterial burden in i.p. inoculated mice were essentially the same between SU6656-treated and the control mice at 72 hr post inoculation (∼ median survival time) (Fig. 6, D).
As reported before [ 4], u-PA-/ mice were essentially resistant to the K/BxN serum transfer arthritis model (data not shown).
Carcinomas in B6SJL- Wnt1-and FBV- Wnt1-transgenic mice were essentially similar and had the classical appearance of a type P tumor.
The mice were essentially devoid of very-long-chain (C22 and C24 -Cer and downstream sphingolipids, whiC24 -Cerso consistent with the substrand specificity of CerS2 towardownstreamain length fatty acyl-CoAsphingolipids
The results were striking: while all of the control mice developed squamous cell carcinomas between 28 and 48 weeks, Cul4a-deficient mice were essentially resistant to UVB-induced skin cancer under these conditions.
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Lab mice are essentially Mus musculus domesticus, while its eastern European counterpart is Mus musculus musculus.
The overall procedure to generate Δ8b and Δ9b knockout mice was essentially as that described by Lecoin et al. [34].
However, attenuated maturation and decreased effector functions in these mice are essentially downstream consequences of reduced number of antigen-specific CD8+ T cells.
While the weight of the 391 mutant mice was essentially lower than that of the wild-type at the same time (Figure 2C), they were also significantly shorter than wild-type mice as evident in Figure 2B, and thus became severely obese at a lower body weight.
Measurement of core body temperature of the mice is essentially the same as describe by Zhuo et al [6] We carried out glucose and insulin tolerance tests (GTT and ITT) by intraperitoneal injection of glucose (1.0 g per kg of body weight) and recombinant human insulin (0.5 unit per kg body weight) into fasting mice (16 hour or 4 hour for GTT and ITT, respectively).
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