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Angiotensin II levels in the kidneys of wild-type and transgenic mice were elevated in a sub-vasoconstrictive range 12 and 18 h after injury.
At 26 weeks of age, hearing thresholds in ISS mice were elevated across all tested stimuli (p<0.001), being highest at the 32 kHz and lowest at the 8 kHz stimuli.
Western blot analysis revealed that APP levels in vehicle-treated Ts65Dn mice were elevated to 225% of vehicle-treated controls (Fig. 1a, b), in agreement with some [17] but not all previous studies [18].
The EGF-family ligand TGF-α (Tgfa) and the kinase Ptk6, which are also increased in both psoriasis and PPARδ transgenic mice, were elevated in SKO mice as well (Table 7) [41].
Levels of the β-secretase and α-secretase cleaved APP C-terminal fragments (C99, C89 and C83) in vehicle-treated Ts65Dn mice were elevated to 260% of vehicle-treated controls (Fig. 1a, b) suggesting that increased levels of Aβ might occur as a result of an enlarged precursor pool.
Interestingly, MDA levels in Sirt3− / − LDLR− / − mice were elevated compared with controls (Fig. 4a).
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Nociceptive response of CRP2-knockout mice was elevated in inflammatory pain model, which indicated that CRP2 contributed to inhibition in pain transmission [31].
Consistent with this, we have shown that retinal levels of cGMP in mutant mice are elevated prior to the development of any overt pathology.
Remarkably, mineral apposition rate in cancellous bone of hypothalamus-specific Y2−/− mice was elevated 2-fold, in parallel with similar changes in cancellous bone volume [31].
In addition, analysis of the frequency of apoptotic cells in the testis of Sirt1−/− and Sirt1+/− mice was elevated (Figure S1).
However, IL-6 protein expression by lymphocytes isolated from low-fat-fed C57BL/6 mice was elevated following 96 h of activation by CD3/CD28 stimulation, which results in activation of the total T lymphocyte population.
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