The mechanism fired only when the mice were dosed with a specific drug.
Pregnant bcl-2 OE or WT mice were dosed (p.o).
In experiments 1 and 2, mice were dosed with morphine (10 mg/kg, i.p).
For growth curves, mice were dosed twice daily with AZD8186 (50 mg/kg) and measured twice weekly using Vernier callipers.
Twenty-eight days female CYP 2E1 +/+ and −/− mice were dosed daily (15 days; ip) with VCH, 1,2-VCM, VCD or vehicle.
Female F344 rats, C57BL/6 mice, or AhR-deficient (−/−, AhRKO) mice were dosed daily (15 days) with vehicle, VCD (80 mg/kg, i.p).
HDM sensitised control mice were dosed with control mouse IgG (10 mg/kg mAb 101.4) accordingly.
The mice were dosed either a single injection of 5 40 mg/kg or weekly injections of 5 mg/kg.
In order to confirm that SMT C1100 had no obvious off target toxicological liabilities mice were dosed with high levels of compound.
Two groups of 6 mice were dosed orally with 1,000 LD50 of ETX, and sacrificed 2 and 6 h later.
Other 4 groups of 6 mice were dosed orally with 0, 12500500 or 2,000 LD50 of ETX in 0.5 ml of 1.5% PBS NaHCO3.
