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Our data indicates that skin γδ T cells in the obese db/db mice were delayed in their ability to round following wounding as compared to lean db/+ control mice (Figure 3A).
The histological changes described above for normal wound healing in control mice were delayed in DAPT-treated mice and accelerated in Jagged peptide-treated mice (Fig. 2; and see SI histological evaluation).
Heart rate reached a maximal level 30 40 sec after the injection, but surprisingly, the arrhythmias in db/db mice were delayed till 5 10 minutes after adrenergic stimulation.
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We now demonstrate T cell responses in plt mice are delayed but ultimately enhanced.
Onset of intestinal cancer in Kaiso-deficient mice is delayed compared to wild-type mice [16].
Tumor development in the Trp53−/+ mice was delayed compared with Trp53−/− mice (Figures 4 & 5).
Correspondingly, weight loss in CD-injected Npc1−/− mice was delayed by approximately 3 weeks.
Importantly, the pathological microglial infiltration in the untreated mice was delayed in the treated mice until the terminal stage.
After a single, low dose injection of 5-FU, hematopoietic recovery in Id1−/− mice was delayed by 3 days, as compared to wild-type littermate controls (Figure 3D).
The regeneration in dy3K/dy3K mice was delayed and not as well-organized as in control and dy3K/δE3 animals, since the muscle fibers in LMα2 chain deficient mice appeared to be less packed and surrounded by connective tissue (Fig. 9A).
This gene has not been implicated in BL, but MDM4 inhibits P53, and in vivo development of B-cell lymphomas in Eμ-myc MDM4+/− mice is delayed compared to that occurring in Eμ-myc MDM4+/+ mice [37].
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