Sentence examples for mice were critical from inspiring English sources

Id1 knockout mice were critical in demonstrating that BM-derived progenitors are the source of tumor endothelium in some tumor types and grades, as Id1 knockout mice failed to mobilize these progenitors and transplantation of Id1 knockout mice with wild type BM was shown to rescue the observed vascular defects [ 8, 18].

In particular, early cognitive assessment in newborn mice is critical to evaluate pediatric drug efficacy and toxicity.

The use of a Fluorinert enema during MRC in mice is critical for differentiating mural processes from intraluminal debris.

In summary, our results demonstrated that expression of HLA class II molecules in humanized mice is critical for development of functional human T and B cells able to efficiently respond to vaccination.

Thus, uncovering the impact of FGFRs on osteocytes using osteocyte-specific Cre mice is critical.

The age of the mice is critical to the disease outcome.

Understanding the molecular basis for the drastic differences between mammary carcinogenesis in WT vs. Nrf2 KO mice is critical.

The p53 tumor suppressor gene (TP53 in humans or Trp53 in mice) is critical for inhibiting tumor development in many tissues.

It has been stressed that the number of mice is critical (at least three), and grouping should be from sexually mature mice from different litters for the induction of SIA.

We demonstrate that re-expression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.

The use of controls derived from the same line as the congenic mice is critical since even the small amount (<1%) of non target C57BL/6 remaining can have profound non-specific effects on phenotype through heterosis.