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Finally, the beneficial effects of DMF in the R6/2 mice were corroborated in the YAC128 mouse as another well established mouse model of HD.
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Although a 42% reduction in Epo release from the microencapsulated cells was observed in comparison with the non-cryopreserved group, the in vivo biocompatibility and functionality of the encapsulated cells subcutaneously implanted in Balb/c mice was corroborated by high and sustained hematocrit levels over 194 days and lacking immunosuppressive protocols.
To overcome the restrictions of in vivo imaging with black mice, the results were corroborated by ex vivo quantification of luciferase activity (Fig. 5B).
Since it is well known that there is no complete neuronal loss, but still severe neurodegeneration in the striatum and the motor cortex of R6/2 mice, the light microscopical data were corroborated by semithin- and ultrasection analysis (Fig. 5).
These results were corroborated in the mouse model of SCD [ Berkeleysickle mice (BK-SS)] and in SCD subjects.
Such results were corroborated by our mouse cortical cultures and immunohistochemical analysis of mouse brain and were in line with previously published expression of spatacsin in non-diseased postmortem human cortical layer V (7).
These beneficial effects were corroborated in YAC128 mice which, after one year of DMF treatment, also displayed reduced dyskinesia as well as a preservation of neurons.
All our results were corroborated in transgenic mice with double doses of the human Tf gene developed by Saleh et al. (2003).
Results seen with the 22-nm CND in the B16 melanoma model were corroborated in a prostate cancer mouse tumor model system.
The observations in transfected COS-7 cells were corroborated for the endogenous Foxl2 mouse homolog by immunoprecipitation in α-T31 pituitary cells (Fig. 1D).
In vitro results were corroborated in vivo in tumor-bearing mice treated with celecoxib.
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