The hypothesis presented here that loss of SGCs in XBP1+/− haploinsufficient mice is conferred by the drug's misreading activity is supported in vivo by the observation that administration of a chemical chaperone significantly alleviated the gentamicin-induced hearing loss.
Thus, resistance to MuLV in the Lake Casitas and Japanese mice was conferred by cells that produce harmless endogenous viral envelope proteins, blocking the binding of the virulent MuLV viruses (Kozak et al., 1984; Ikeda et al., 1985; Dandekar et al., 1987; Ikeda and Sugimura, 1989).
The later onset and reduced seizure frequency in D/+ mice compared with D/− mice demonstrates that protection is conferred by the presence of the wild-type Nav1.6 channel (Table 1).
In transgenic mice, slow-specific expression is conferred by a 128 base pair (bp) rat sequence from the TnI slow gene dubbed the slow upstream regulatory element (SURE), and fast-specific expression by a 144 bp sequence from the fast TnI in quail called the fast intronic regulatory element (FIRE) (Banerjee-Basu & Buonanno, 1993; Hallauer & Hastings, 2002; Nakayama et al., 1996).
Mouse neuropathogenicity could possibly be conferred by reduced particle stability of PV1 LS-a) inasmuch as we found PV1 LS-as to be thermolabinasmuch
No protection was conferred on mice by antitoxins to botulinum toxins A, B, or E. A stool sample collected on hospital day 1 tested negative for botulinum toxin but yielded C. baratii that produced botulinum toxin type F. Public health officials did not identify any suspect food or other potential source of exposure.
Moreover, pluripotency can be conferred upon mouse and human somatic cells through overexpression of c-Myc and three other transcription factors (Oct4, Sox2, and Klf4) [12] [15].
EcoHIV tropism to mouse cells is likely to be conferred not only by the cell surface receptor but also by the activity of the viral long terminal repeat (LTR), as is common for retrovirus replication in mice (Celander and Haseltine, 1984); EcoHIV encodes the HIV LTR.
More importantly, strong and sustained anti-CHIKV protection was conferred in suckling mice pretreated with different concentrations (3.1, 9.5 and 19 pmol) of shRNA (E1).
We thus reasoned that the observed increase in hepatic Abcb11 protein expression in mice treated with aspirin may have been conferred by either LTs or LXs, or both.
