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Heterozygous Pold1+/− mice were apparently normal and fertile with no detectable developmental abnormalities over 18 months.
The retinal laminar structure and the distribution pattern of GFP-positive cells in SPIG1gfp/gfp mice were apparently normal (data not shown).
Since chronic cigarette smoke exposure did not promote further increases in airspace enlargement in Egr-1−/− mice, these mice were apparently resistant to smoke-induced injury.
The function of Nanos2 in brain development is unknown, as the Nanos2 knock-out mice were apparently normal except for male infertility [25], and no phenotypic abnormality was reported for Nanos2 transgenic mice, which over-express Nanos2 under the control of Oct4DeltaPE promoter, but the expression was not examined in brain [27].
No detrimental effects of Twinkle overexpression were noted as transgenic mice were apparently normal.
The general behaviours, blood test results and responses to starvation of the IF1-KO mice were apparently normal.
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IL-6 null mice are apparently normal in terms of their survival, development, skeletal phenotype and response to catabolic PTH [17].
Comparing the size of the evident GJ plaques between WT (Fig. 2A) and Cx30 null (Fig. 2B) mice, the density of Cx26 immunoreactivities in the Cx30 null mice was apparently decreased.
Given the fact, that the phenotype of Col1a1-Krm2 mise is apparently more severe than the phenotype of Col1a1-Dkk1 transgenic mice reported in the literature [26], it was also important to compare the genome-wide expression analysis of wildtype and Col1a1-Krm2 transgenic osteoblasts to another Gene Chip hybridization experiment, where we have treated wildtype osteoblasts with Dkk1 for 6 hours.
However, one out of four treated mice is apparently cured at 193 days post-injection.
The cardiac phenotypes of Fgf2 knockout mice are apparently opposite to that of Fgf16 knockout mice reported here.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com