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Surprisingly, mortality rates in WT mice were achieved at a pilocarpine dose of 250 mg/kg.
Generation of ptch1 +/-/p53 +/- mice were achieved by crossing p53-/ and ptch1+/- mice as previously described by Wetmore, Eberhart and Curran, 2001 [ 38].
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Pain control for CLP and sham mice was achieved with 0.05 mg/kg buprenorphine every 12 h.
Tracking a single QD conjugated with tumor-targeting antibody in tumors of living mice was achieved using a dorsal skinfold chamber and a high-speed confocal microscope with a high-sensitivity camera [175].
Visualisation of α-amino-3-hydroxy-5-methylisoxasole-4-propionic acid binding sites in the brains of A2aR k/o mice was achieved by utilising quantitative receptor autoradiography with (S -[3H]-5-fluorowillardiine ([3H]FW:10 nM) on S -[3H]-5-fluorowillardiineouS -[3H]-5-fluorowillardiine
Therefore, marked growth inhibition of SKOV-3 tumor xenografted in Balb/c nude mice was achieved with negligible side effects on the mouse health after intravenous administration of PUBAP based polyplexes with a therapeutic plasmid encoding for TNF-related apoptosis-inducing ligand.
A sophisticated spatio-temporal elucidation of HTLC release in tumor-bearing mice was achieved by way of real-time monitoring using a magnetic resonance (MR) imaging protocol, wherein a custom-built laser-based conformal heat source was applied at the tumor volume to trigger the release of HTLC co-encapsulated with the MR contrast agent gadoteridol (Gd-HP-DO3A).
Lethal infection of SCID mice was achieved after i.n.n
Euthanasia of all mice was achieved under deep pentobarbital (150 mg/kg) anesthesia.
Euthanatasia of all mice was achieved under deep pentobarbital anesthesia and perfusion was not performed to avoid mechanical disruption of blood capillaries.
Nasal inoculation of mice was achieved by instilling 5 µl per nostril of the same 25,000 pfu/µl solution of HSV-2 MS or 0ΔNLS from a micropipettor.
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