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The laboratory's director, Dr. Kenneth Paigen, said mice were a better vehicle for gene analysis than people because mouse tissues can be analyzed in a fresher state and the cells' perishable gene transcripts captured more efficiently.
The treatment was started when the normal mice were a year old, and they have now been treated for five months.
Sap -/- mice were a kind gift of Dr. Pamela Schwartzberg (NIH).
I mainly liked looking over the patent because they use illustrations that hearken back to the days of yore, when multi-touch mice were a novel proposition.
Gadd45a−/− mice were a kind gift from Professor Albert J. Fornace, Jr. and ATM−/− mice were purchased from the Jackson Laboratory.
The mice were a strain previously engineered to produce a bright green fluorescent marker in any active neurons.
H1-receptor gene deficient mice and H2-receptor gene deficient mice were a gift from Prof. Kazuhiko Yanai, Tohoku University [15, 16], and the progeny of the colony was maintained.
LTH1 mice were a gift from Diane Mathis (Harvard).
MR (CD206) KO mice were a gift from M.C.
Sh2d1a−/− mice were a kind gift from C. Terhorst.
MyD88 KO and TLR9 KO mice were a gift from S. Akira (Osaka University).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com