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In combination treated mice we observe both less advantageous CD8+ T-cell to MDSC ratios (1.4 vs. 6.9) and CD4+FoxP3- effector T-cell to MDSC ratios (0.24 vs. 0.66) with GVAX versus FVAX (Figure 8C&D).
In each generation of MaD1 mice, we observe extreme neglect in a consistent proportion of the population and the background population from which MaD1 mice were derived may have altered dopamine signaling, for review, see [67].
Coincident with neuronal loss in G2019S LRRK2 mice, we observe the accumulation of autophagic vacuoles and evidence of increased mitochondrial autophagy and damage in the brains of transgenic mice by electron microscopy.
In mutant PC3/Tis21 mice we observe that the number of stage 5 neurons of 1 5 days of age increases strikingly (about 2-fold), in comparison with normal mice, and remains higher also at 28 days of age, when the number of stage 5 neurons increases to represent 1/4 of stage 6 neurons.
However, when Rapa is given to DR mice, we observe a large number of new metabolites.
In normal unmanipulated mice, we observe strong uniform activin A and TGF-β immunostaining in the airway epithelium.
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Consistent with our observations in the WAT of Tg mice, we observed down-regulation of Rip140 and up-regulation of Pgc1a.
When comparing RAGE KO and WT mice, we observed no significant differences regarding alveolar barrier dysfunction.
In 28-week-old Fabry mice we observed significantly decreased Gb3 accumulation.
In PPAR-α /– mice we observed delayed stratum corneum formation between day 18.5 of gestation and birth.
Following transplantation of ARSA-overexpressing precursors into ARSA-deficient mice we observed a significant reduction of sulfatide storage up to a distance of 300 µm from grafted cells.
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