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In moribund mice, we find that 19.5±2.4% of CD3+ brain lymphocytes expressed OX40.
In mice, we find suggestive evidence that for hundreds of gene expression traits, robustness is polymorphic and can be genetically mapped to discrete genomic loci.
In fact, in wild type mice we find that stage 5 neurons (BrdU+/Calr+/NeuN+) of 1 5 days of age are a small fraction of the terminally differentiated stage 6 neurons (BrdU+/Calr−/NeuN+), being less than one third.
Using conditional ablation of langerin+ cells in lang-DTREGFP mice, we find that a significant proportion of the CD8+ T cells responding to intravenous injection of antigen-loaded BM-DCs are primed by endogenous langerin+ DCs.
In these mutant mice we find severe developmental defects in essential motoneurons of the hindbrain with impact on respiratory regulation, an observation which underlines the phenotypic abnormalities seen at birth.
Using a conditional deletion approach in mice, we find in homozygous Dicer mutants a marked increase of ipsilateral projections, RGC axons extending outside the optic chiasm, the formation of a secondary optic tract and a substantial number of RGC axons projecting aberrantly into the contralateral eye.
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Using OEG and DRG from L1 mutant mice we found that L1 expression does not contribute to OEG growth promotion.
In our subsequent monitoring study of DCM mice, we found a significant decrease of LVEF in the EPO group, but not in the saline-treated mice.
However, when we inspected the STAT3 decoy previously shown to resolve psoriasiform lesions in mice, we found that the decoy sequence most closely matched STAT1 PWMs (Figure 5D).
Constructing ConA-induced hepatitis model on Treg-depleted mice, we found that depletion of Tregs upregulated CD4+CD69+ T cells in the liver and spleen (Fig. 5B).
Following a combination of two mucosal and two systemic vaccinations of mice, we found significant enhancement of both local and systemic antibodies as well as cytokine responses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com