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To bypass the embryonic lethality of nonconditional Ate1−/− mice, we employed the Cre-lox technique [24].
To evaluate the rewarding properties of cocaine in NR1DATCre mice, we employed a CPP paradigm (Fig. 9).
To evaluate the cognitive performance of treated and control mice, we employed the Morris Water Maze (MWM) test.
To assess the social affiliative behavior of HB-EGF KO mice, we employed a social interaction paradigm.
For testing the nicotine conditioned place preference in DA-NR1-KO mice, we employed an asymmetric contextual place preference apparatus and used three groups of littermates (Slc6a3cre alone, Slc6a3Cre with fNR1/+, and wild type) as controls.
In order to validate our initial observations of hyperphosphorylation of tau at residues associated with AD in sod2 null mice, we employed mass-spectrometry techniques as an alternate approach.
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To investigate whether analogous scMRI networks are present in lower mammal species amenable to genetic and experimental manipulation such as the laboratory mouse, we employed high resolution morphoanatomical MRI in a large cohort of genetically-homogeneous wild-type mice (C57Bl6/J) and mapped scMRI networks using a seed-based approach.
This is why, in order to identify a distinguishing transcriptomic signature of the MRL/MpJ mouse we employed two different reference strains.
Systemic administration of pharmacological agents induced behavioral hyperactivity in habituated DAT-KO mice, thus we employed a modified experimental paradigm.
To test whether TBL1 upregulation is a conserved feature between human and mouse PDAC, we employed p48+/Cre; Kras+/LSL-G12D mice.
To examine the effects of global p53 gene deletion at specific ages in mouse tissues, we employed the strategy outlined in Fig. 1A.
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