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"Once we have those mice, we can get the basic knowledge we need in order to tweak mammals to make them live longer.
In the context of female mice, we can achieve ablation of mammary adipocytes relatively selectively without affecting other fat pads.
For PrPc-deficient mice we can consider a "loss of function phenotype".
Although the latter will be non-functional in SLE-afflicted mice, within the healthy injected mice we can still expect suppression of CD4 effector cells by CD4 Tregs.
As an important target of ASA was removed in these mice we can only speculate that the "off target" effects of ASA we have observed are those that mediate the mortality in response to infection.
Comparing the biological litters of C57 and DBA mice, we can see that the overall lower bodyweight of DBA mice is due to a strain difference, rather than a difference in nursing posture.
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What does concern me is a growing belief that with the click of a mouse, we can make the bad things go away.
Despite Folkman's demur, "If you have cancer and you are a mouse, we can take good care of you," he was simultaneously applauded by admirers as a hero and reviled by critics as a grandstander.
The Heckscher show includes sparkling examples of all three, inviting visitors to think about what the word "original" means in a world where, with the click of a mouse, we can all "own" the Mona Lisa.
Literally, with the touch of a fingertip or the click of a mouse, we can be connected to someone from another country, stream live footage to family members, or update friends with pictures and statuses.
LU: When I was watching Sarah Palin's acceptance speech at the RNC convention, my prevalent thought was, "what do our global friends and foreign leaders think?" We are living in the age of the global world, where for a few dollars we can cross boundaries, cultures, and countries; with the click of a mouse, we can connect with friends, allies, and supporters in the four corners of the earth.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com