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Since HPB regimen showed higher IL-4 after vaccination, and substantially lower IL-4 after challenge infection, early mixed Th1/Th2 responses exhibited by this groups of mice was therefore skewed in Th1 biased response after L. donovani infection.
The finding of proteinaceous aggregates containing SOD1 in motor neurons of postmortem fALS patients and transgenic mice was therefore a major advance in the field since it suggested that aggregation of SOD1 is related to the pathology of SOD1-linked fALS [10].
Impaired survival in celecoxib-treated mice was therefore likely due to drug toxicity.
The ability of SRTAW04 to attenuate neuronal loss in MHV-A59 infected mice was therefore examined.
Locomotor activity in Id2−/− mice was therefore quantified using the open-field test.
Tumour onset in E μ- Myc, E μ- Myc/Bik−/− and E μ- Myc/Bik−/− Noxa−/− mice was therefore stratified according to pre-B or B lymphoma subtype.
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Increased BAFF levels in WAS KO mice were therefore unexpected.
I couldn't help but feel a tension between the claims that the mouse genome is far more similar to the human genome than scientists previously believed and that mice are therefore an excellent surrogate for studying the human genome in tests that would be unethical to conduct on human beings.
HHD mice are therefore useful for studying immunisation strategies for inducing and maintaining CD8 responses to over-expressed self antigens.
RO5126766 treatment (1.0 mg/kg) did not inhibit growth of the COLO320DM tumors (Figure 2a) and these mice were therefore sacrificed after 6 days of treatment when the tumors had reached the size limits allowed by research ethics.
All experiments involving doubly mutant mice were therefore performed on F1 mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com