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Notably, adoptive transfer of wild-type Treg into CD81-deficient mice was sufficient to promote tumor growth and metastasis.
Interestingly, systemic infusion of absorbed amounts of LPS in mice was sufficient for diet-induced obesity and metabolic syndrome, even when the mice were fed standard diets [32].
Importantly, injection of WT DCs into PLCγ2−/− mice was sufficient to rescue the inflammatory response, leading to massive cellular infiltrate in the joint space (Figure 7).
In either case, the 30% reduction of Bhlhb5+ amacrine cells in LMO4 cko mice was sufficient to impact the retinal visual signals as shown by ERG.
Previously, we had shown that a single AAV injection into the cerebral lateral ventricles of neonatal GM1 mice was sufficient to correct the neurochemical phenotype [17].
The expression of only one transgenic chromosome 16 in heterozygous F1 mice was sufficient to allow development of similarly diverse neoplasms.
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Direct administration of C18 1-Gln to miC18 1-Glnficientoto recapitulate a subset of phenotypes observed in Pmice1-KO anisalsufficient
It has been shown that the level of IL-7 in Rag2KO mice is sufficient to cause IL-7Rα downregulation in adoptively transferred naïve T cells4.
The number of animals injected with the tumor cells were determined based on our experience, where 6 mice are sufficient to demonstrate approximately 50% difference in tumor growth.
Why this treatment only works in older mice will be a topic for additional study although it might be that the normal circulating levels of GDF11 in young mice are sufficient.
Furthermore, restoration of Crim1 levels in just the lens tissue of Crim1KST264 mice is sufficient to ameliorate most of the dysgenesis observed in the mutant animals.
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