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A minority of WT mice was of pure strain stock, rather than derived from backcrossing.
The overriding phenotype of these mice was of rapid onset of bladder EMT and neoplasia, both of which we show to be dependent upon MTOR activity.
The reduction in β-cell surface observed in Sei1-null mice was of intermediate magnitude when compared with the severe defect characteristic of Cdk4-null mice (Fig. 8C).
These mice were back-crossed more than six times with C57BL/6 strain before experiments were done to make sure that the majority (>98%) of the genetic background of generated mice was of C57BL/6 origin.
Consistent with the previous description of the IκBα-SR Tg mice [58], the thymus from double-transgenic mice was of normal size and the absolute thymocyte numbers were not significantly different compared to wild-type mice.
38 40 The enamel in Klk4 null mice was of normal thickness and had decussating enamel rods as expected.
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HDC−/− mice and H1R−/−/H2R−/− mice were of a genetic background of a C57BL/6 J strain, and their littermates were used as wild-type (WT) controls.
Outside the city, however, rats (and mice) are of some ecological benefit.
The mice were of a mixed C57BL/6J and 129SvJ background.
All mice were of the strain background C57Bl/6;129X1SvJ.
In our experiments, control mice were of either the genotype Adam17flox/+ or Adam17flox/flox (without Foxn1-Cre).
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