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Before the efficacy studies, we determined that the maximal tolerated dose in C57BL/6J mice was less than 400 ppm.
Interestingly, however, we found that the immune response of heterozygous AhR+/− mice was less sensitive to TCDD than homozygous AhR+/+ mice.
In contrast, the reduction of muscle mass of Nlrp3 KO CLP compared to Nlrp3 KO sham mice was less severe (Fig. 3e, f, Additional file 4C, D).
Additionally, high VT-induced increase in the concentrations of protein, IL-6 and MIP-2, observed in ventilated, untreated WT mice, was less in mice pretreated with the Tpl2 inhibitor (Figures 4 and 5).
However, milk-content in the stomach of knockout mice was less in comparison to control littermates.
Aire mRNA expression in TECs in Adam17/Foxn1 mice was less than 10% of control mice.
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Some obesity researchers, though, say there may be other reasons that the mice were less fat.
When the histone modification was chemically blocked, the mice were less likely to become addicted.
KO mice were less physically active than WT in cages with or without running wheels.
Activated mice are less likely to interact with intruders, while lower activation causes mice to ignore pups in favor of interacting with other mice.
The genetically modified mice were less anxious than the normal mice and were more resilient in the face of social stress.
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