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In this report, the impaired immune tolerance of NZB/W mice was exploited to generate monoclonal antibodies against highly conserved or self-antigens.
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He was exploited".
Who was exploited?
New coal mines were exploited.
Herein, we propose accelerated aging phenotype mice can be exploited to bypass these limitations.
The proenkephalin-eGFP mouse has preferential matrix expression [25] and the early innervation by dopaminergic fibers using the Tyrosine Hydroxylase (TH -eGFP mouse has been exploiTH -eGFPdentify striosomouseevelopmentally [26].
How can transgenic mouse models be exploited to dissect selective vulnerability and identify genes and proteins that either protect from degeneration or confer an increased risk?
Finally, knockdown of these proteins in human cord blood-derived CD34+ cells enabled superior reconstitution of rag2 −/− γc −/− mice suggesting conserved functions of Bim and Bmf between humans and mice that may be exploited therapeutically to reduce HSCT-associated morbidity.
However, heterologous skin equivalent models have the unique advantage, that genetically modified mouse cells can be exploited such as embryonic fibroblasts from knock-out or transgenic mice.
Further, mouse genetics are being exploited to gain insights into the genetics of COPD susceptibility.
In the discovery of these therapies, preclinical mouse models may be exploited to accelerate drug development.
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CEO of Professional Science Editing for Scientists @ prosciediting.com