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Nociceptive response of CRP2-knockout mice was elevated in inflammatory pain model, which indicated that CRP2 contributed to inhibition in pain transmission [31].
In addition, analysis of the frequency of apoptotic cells in the testis of Sirt1−/− and Sirt1+/− mice was elevated (Figure S1).
Remarkably, mineral apposition rate in cancellous bone of hypothalamus-specific Y2−/− mice was elevated 2-fold, in parallel with similar changes in cancellous bone volume [31].
However, IL-6 protein expression by lymphocytes isolated from low-fat-fed C57BL/6 mice was elevated following 96 h of activation by CD3/CD28 stimulation, which results in activation of the total T lymphocyte population.
Additionally, using a second approach, VEGF-induced angiogenesis in scrambled control-siRNA (Con siRNA) injected sponges in β3-null mice was elevated when compared with Con siRNA treated sponges in wild-type mice, and Rac1-specific-siRNA injection into sponges inhibited significantly angiogenic responses in β3-null, but not wild-type, mice (Figure 6B).
We found that the urine protein-to-creatinine ratio of Clic4 null mice was elevated more than 3 fold.
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Angiotensin II levels in the kidneys of wild-type and transgenic mice were elevated in a sub-vasoconstrictive range 12 and 18 h after injury.
Consistent with this, we have shown that retinal levels of cGMP in mutant mice are elevated prior to the development of any overt pathology.
The EGF-family ligand TGF-α (Tgfa) and the kinase Ptk6, which are also increased in both psoriasis and PPARδ transgenic mice, were elevated in SKO mice as well (Table 7) [41].
At 26 weeks of age, hearing thresholds in ISS mice were elevated across all tested stimuli (p<0.001), being highest at the 32 kHz and lowest at the 8 kHz stimuli.
Western blot analysis revealed that APP levels in vehicle-treated Ts65Dn mice were elevated to 225% of vehicle-treated controls (Fig. 1a, b), in agreement with some [17] but not all previous studies [18].
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