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Brain ascorbic acid content in embryonal SVCT2-deficient mice was dramatically reduced [38].
Furthermore, blood vessel formation in NOX1-deficient mice was dramatically reduced in response to angiogenic factors and in tumors.
The elevated IOP of 7-week-old Vav2−/−Vav3−/− mice was dramatically reduced by ocular hypotensives used in humans, such as latanoprost, a prostaglandin analogue (Figure S4A).
More interestingly, the total level of TrkB phosphorylation in tat-cyclotraxin-B-treated mice was dramatically decreased as compared to saline or tat-empty-treated animals (Fig. 7B).
Combining these findings with our data directly showing that intercellular GJ-mediated 2-NBDG diffusion among supporting cells in the Cx30 null mutant mice was dramatically reduced (Figs.
The number of neurons with intense Tph2 immunofluorescence in the raphe nuclei of Lmx1b iCKO mice was dramatically reduced compared with control mice (Figure 4).
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Moreover, humoral immune responses in these mice are dramatically impaired.
Normal mice have spontaneously high levels of alternation, whereas hippocampal-lesioned mice are dramatically impaired.
Furthermore, osteoclasts in Ae2-/ mice were dramatically enlarged and fail to form the normal ruffled border facing the lacunae.
The spines of both semaphorin-lacking and neuropilin-lacking mice were dramatically enlarged, compared to those of the smaller, spherical-looking spines in the wild-type mice.
The metabolic abnormalities seen in the exposed female mice were dramatically exacerbated when they were fed a high-fat diet for 12 weeks in adulthood.
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