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Tumor growth in intact mice was detectable 4 weeks post-implantation using BLI with an average luminescence intensity of 2 × 10 photons/second.
YopM-Cy5 injected into the hind paws of hTNFtg mice was detectable in the joint without a systemic distribution for 48 hours and elimination mediated through renal clearance.
PSI-induced loss of dopaminergic neurons in PLP-hαSYN transgenic mice was detectable 2 weeks after treatment (28%%) and progressed up to 54 % neuronal loss at 12 weeks.
We found that GFAP in the CSF of Gfap +/+ mice was detectable in all four pooled samples (354±217 ng/l, means±S.D ., whereas GFAP in the CSF of all three AxD models was significantly elevated compared with controls, and in the same rank order as expected from brain (1264±596 for Gfap R76H/+; 2637±1001 for Gfap R236H/+; 46676±40533 for GFAP Tg mice; n=9 14 in each group).
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Next, we asked whether T cells in the synovial fluid of inflamed ankles of SCID mice were detectable by flow cytometry.
Changes in marrow cellularity of collagen X Tg and KO mice were detectable both histologically and by flow cytometry.
The pancreas of both wild-type and Dicer1-hypomorphic mice developed normally and endocrine and exocrine cells appeared morphologically normal at E15.5 and P1 (Fig. 6A, B); the same abnormalities observed in adult Dicer1-hypomorphic mice were detectable at 4 weeks of ages (Fig. 6C), although the number of abnormal cells was less than that found in adult Dicer1-hypomorphic mice.
We assume that the observed striatal transcriptome changes are secondary effects of compromised DA signaling through nigrostriatal A53T-SNCA overexpression since human SNCA immunoreactivity in the striatum of PrPmtA and PrPmtB mice is detectable only in synapses, but not in neurites or cell bodies [13].
The motor deficit in N171-Q82 mise is detectable at 10 11 weeks of age (Schilling et al., 1999).
Our findings in this study are congruent with these data: a very small number of transferred T- and B-lymphocytes derived from either control or glaucomatous mice are detectable in the ganglion cell layer of recipient mice.
We also observed that although Venus fluorescence was found in about 80% of GLP-1-positive cells from GLU-Venus mice, it had a lower penetrance in GIP-Venus mice, being detectable in only approximately 30% of GIP-immunopositive cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com