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Moreover, the enhanced cell proliferation by phenobarbital in the liver of wild-type mice was completely abrogated in the double-humanized CAR and pregnane X receptor (PXR) mouse model (Ross et al., 2010).
The defective osteoblastic differentiation, mineral deposition, and osteogenic gene expression in calvarial cultures derived Pkd1-deficient mice was completely reversed by superimposing Kif3a deficiency.
In addition, secretion of IFN-γ by cells from CCIA mice was completely inhibited by coculture with treated cells (p<0.05).
Our findings reveal that Tax transgenic mice develop rheumatoid-like arthritis with proliferating synovial cells in the joints; however, the proportion of different splenic T-cell subsets in these mice was completely different from other commonly used animal models of rheumatoid arthritis.
In contrast, the sniffing pattern of the tro/tro mice was completely different.
In addition, spontaneous arthritis in IL-1Ra-deficient mice was completely blocked in the absence of IL-17 [ 53].
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In one experiment, "half the mice were completely cured, with no evidence of tumor regrowth after a further three months," Dr. Vogelstein and his colleagues wrote in an article last month in The Proceedings of the National Academy of Sciences.
A "vast majority" of the children of the older mice were "completely normal," he said, which meant their score fell under the upside-down parabola of the curve.
Upon immunization with self-adjuvanted SAPNs, mice were completely protected against a lethal challenge.
When the researchers interfered with the a3 receptor's ability to pick up Valium, the mice were completely normal.
We confirmed that CAG MnSOD knockout mice were completely deficient in MnSOD and died as neonates, validating the use of the Cre loxp system.
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Justyna Jupowicz-Kozak
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