CDDP in mice is augmented when the drug is administered in hypotonic solution.
The systolic aortic pressure wave of the heterozygous mice is augmented, while the diastolic relaxation is significantly slowed (Munir et al, 2007; Fig 6B).
For example, it has been demonstrated that the pressor response to AngII in adult mice is augmented by OVX and restored by estrogen replacement [ 9],[ 26].
Three-week treatment did not elicit significant differences the expression of α1, α2 or α5 subunit mRNAs in animals of either sex, although there was a trend toward decreases in all three subunit mRNAs in female mice, which was augmented and attained significance for the α2 subunit mRNA in females treated for six weeks.
In Hoxa5−/− mice, SPDEF expression was augmented at sites of goblet cell metaplasia whereas the NKX2.1 protein, normally expressed in Clara cells, was not detected in goblet cells.
In another experimental aging study on C57BL/6 female mice [ 26], the pressure was augmented in 16-month-old mice compared to 6-month-old group.
In addition, the growth plates of Igf-I-deficient mice display reduced hypertrophy [52], whereas hypertrophy was augmented in the Slc39a14-KO mice.
The production of antigen specific IFN-γ, IL-2 and IL-4 was augmented in mice orally administrated with plasmid expressing murine IL-2/Ig (Wierzbicki et al., 2002).
In wild-type mice, pressor responsiveness to AngII was augmented with age, such that the pressor response to AngII was similar between aged AT2R-KO and wild-type female mice (31 ± 4 mmHg versus 34 ± 3 mmHg, respectively, on day 14, P = 0.9).
We found that, the number of TUNEL-positive cells was augmented significantly in mice after 12 and 24 h post TBI compared with sham controls.
