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After CsA administration, the peak brain uptake in mice was at 1.5 min and at 1.2 min in rats.
The first detected TCR expression in Rec-HY mice was at the DN4 stage of development.
We have reported that the onset of autoimmune lesions in lacrimal and salivary glands of CCR7−/− mice was at around 10 weeks of age [26].
We found that treatment with DOPS also restored a normal torpor recovery rate in Dbh −/− mice; arousal from torpor in DOPS-treated Dbh −/− mice was at a rate similar to that of wild-type mice (Fig. 3B).
Although the growth plate was not affected (Fig 1D), bone formation parameters (MAR&BFR) of the trabecular bone were decreased (Fig 1E), indicating that osteopenia in the Akt1-/ mice was at least partly due to the impairment of osteoblastic bone formation.
The onset of neurological impairment in B−/− mice was at ∼12 months of age as manifested by an unsteady gait.
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When infected humans or mice are at their sickest, they're already well on their way to eliminating the microbes that cause the disease.
Here we show that a large fraction of medial entorhinal cortex neurons fire specifically when mice are at given distances and directions from spatially confined objects.
However, recent results using this model in adult mice are at odds with the same model in neonatal rats.
The increased heart rate leading to a positive inotropic effect in the hearts of transgenic mice is, at least in part, due to the overexpression of adrenergic receptors.
Adult mice were at the proestrus stage of menstruation at the time of sacrifice.
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CEO of Professional Science Editing for Scientists @ prosciediting.com