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In the present study, we confirmed that the IP3R1 mRNA in opisthonos (opt) heterozygote mice was approximately 50% reduced as compared to that in wild-type mice.
At 6 h p.i., near-infrared (NIR) fluorescence signal intensity in the tumor tissues of Ms20-QD-treated mice was approximately 3.6-fold higher than in QD-treated mice.
When HeLa tumor volume of the HeLa tumor-bearing mice was approximately 60 mm3, the mice were randomly divided into four groups and treated by intravenous injection of 0.9% NaCl, free HCPT, NDs, and HFNDs every 3 days at a dose of 80 μg HCPT per mouse.
The daily food intake of CXCL14−/−Ay mice was approximately 86% of that of CXCL14+/−Ay mice.
The size of the striatum in wildtype mice was approximately 7×109 µm3 and is significantly smaller in HD mice (approximately 5.3×109 µm3).
On post-injury day 1 the size of wounds in UA2-treated mice was approximately 15% smaller than wound size in control mice (Fig. 3A, B).
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At the time of the experiments, the mice were approximately 9 weeks old.
The gestational period of C57BL/6 mice is approximately 19 days and date of birth is designated as postnatal day 0 (P0).
The mean lethal dose (LD50) in mice is approximately 1000 fold lower by injection or inhalation than by oral administration [5].
Similarly, we found that wild-type and lmna−/+ mice were indistinguishable 24 days after birth, whereas lmna−/− mice were approximately half their size (6.3±1.2 g).
The percentage of HSCs from both EL4-bearing mice and control mice were approximately equal, suggesting that the HSC pool was not affected by tumor growth.
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