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Preservation of function in demyelinated perforin-deficient mice, as compared to demyelinated perforin-competent mice, was apparent by stride length and footstep positioning (Figure 1J-L), by open-field video analysis (Movie S1), by runway video analysis (Movie S2), and by direct observation of posture (Figure S2).

The aggregate formation in E4B Tg mice was apparent specifically in certain hypothalamic nuclei.

Intraneuronal pAβ in APP23 mice was apparent as previously reported in APP-PS1 transgenic animals [ 28].

Telomere shortening in mTerc−/− mice was apparent only after several generations of inbreeding, as telomeres shorten at a rate of 4.8 ± 2.4 kb per Terc −/− generation (Blasco et al., 1997).

The effect on sEPSC amplitude in wild-type mice was apparent from the rightward skew in the amplitude histograms (11.6 15.1 pA) (Fig. 3C), but this was negligible in P2X4−/− mice.

However, the increase in arterial pressure in reproductively senescent female mice is apparent at 18 months of age, at which time the sexual dimorphism in arterial pressure is lost in mice (arterial pressure measured via radiotelemetry, unpublished data).

Comparison of the phenotypes displayed by the mutant mice revealed that the oral adhesions in Irf6R84C/R84C mice were apparent from the earliest stages of, and persisted throughout, development of the secondary palate.

In order to quantitate these changes, parameters were scored as a measure of disease severity and differences between sdc-3 null and wild-type mice were apparent (Table  1).

Deficits in photopic (70 cd/m) contrast sensitivity of DKO mice are apparent at stimuli speeds of >12 deg/s (error bars are SEM; t-test: **p < 0.01, ***p < 0.001, n = 4 5).

Signs of preneoplastic lesions in MnSOD-KO mice were apparent already 3 months after injection of DEN, whereas in control animals, the first preneoplastic lesions appeared after 6 months.

The downregulation of the expression levels of c‐Myc and cyclin D1 in the small intestinal tumors of Min mice were apparent compared with those of the untreated group (Fig. 1b,c).