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We postulated that the gradual depletion of germ cells in aging VRK1-deficient mice was accelerated by dysfunctional undifferentiated spermatogonia.
AA-amyloidosis in group G mice was accelerated by AEF injections and it may be argued that injected AEF is transferred from these animals to group H mice.
In fact, the tau pathology of 6 months-old STZ-treated pR5 mice was accelerated as it was comparable to that normally only found in pR5 mice above an age of one year [20], [21], or in pR5 mice intracerebrally injected with aggregated Aβ to exacerbate a pre-existing tau pathology [22].
Differentiation in the developing pancreas of Aldh1b1 tm1lacZ null mice was accelerated.
These studies demonstrated that the decay of desmin in HET and HOM mice was accelerated when compared to WT animals.
Recovery of mice was accelerated by administration of atipamezole (Antisedan™, 5 mg/ml) at the rate of 1 mg/kg of body weight.
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It was observed that retinal degeneration in P347S transgenic mice is accelerated in the absence of Trα [57].
Two possibilities for enhanced cell proliferation in Cdk4R/R mice are accelerated proliferation of active cells and recruitment of quiescent cells into active cell population.
Tumor formation in mice is accelerated by coincident p53 mutandon[10] and it has been recently proposed that tumor formation associated with loss of SMARCB1 may arise due to permissive defects in cellular DNA damage response pathways [11].
However, considering the high pathogen burden in these mice, it needs to be investigated in future studies whether one of the factors contributing to poor development of memory CD8+ T cells in IL-7 depleted KO mice is accelerated exhaustion of CD8+ T cells via PD-1-PDL-1 pathway [46], [47].
Growth and progression of orthotopic- and genetically-induced mammary tumors in female MKR mice were accelerated as compared to controls, but were blocked using pharmacological inhibitors of insulin signaling or insulin-sensitizers [ 17, 18].
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