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Successful propagation of primary tumor samples as xenografts in immune-compromised mice varies from 10%to30%0%, depending on the tumor type and technique used [19].
Certainly, the frequency of cancer stem cells, as assayed by transplantation in immune-deficient mice, varies from very low (approximately 1 in 10) (Ishizawa et al. 2010; Sarry et al. 2011) to very high (approximately 1 in 4) (Quintana et al. 2008).
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Interestingly, the phenotype of Smad7liver-KO mice varied from mouse to mouse.
Tumour response in these mice varied from 85% cures to no significant growth delay, depending on the drug light interval, whereas the tumour drug levels remained constant.
The mean IP of UK-1 and UK-2 in TgshpXI mice varied from 166 to 196 days while the IP of ovine BSE in this mouse line exceeds 300 days (28).
The characteristics of the leukemia developed by each set of mice varied from patient to patient and xenotransplanted cells retained the fundamental biological characteristics of the original disease including the patient-specific pattern of CXCR4 expression and CXCL12-mediated chemotaxis.
Floor space area per mouse varied from 180 to 1250 cm, with the floor space largest in the study by Cao et al., which was about five times that of our study.
Not surprisingly, the tissue distribution profile of 68Ga-PSMA-11 68Ga-PSMA-11 68Ga-PSMA-11tly from those of the other investigated radioligands, as was observed previously in preclinical experimices [15, 20].
However, in comparison to 4-week old animals, cre expression in older mice varied considerably from animal-to-animal.
Although the congenic mice varied genetically from the control strain at only one or two NOD loci, there was a substantial difference in gene expression.
Likewise, the sperm output in the cauda epididymus from Tex19.1−/− mice varied greatly, ranging from 3.0×105 to 1.2×107, but correlated well with the testis size.
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