Sentence examples for mice validating the from inspiring English sources

The simulated data fit accurately to the observed data for both lean and obese mice, validating the use of the mathematical model in mice at different stages of diabetes progression.

Our results revealed an increase in TNFα mRNA in the brains of Dox-induced mice, validating the functional activity of Tat in these animals (data not shown).

In contrast, ATRX protein levels in brain and bone (calvariae) were unchanged in mutant mice, validating the tissue specific activity of the Col2a1 Cre (Figure 2B).

A distinct population of tetramer-positive cells (typically 0.5 2% of spleen CD8+ T cells and 2 9% of brain CD8+ T cells) was seen in infected but not naïve mice, validating the epitope specificity.

Furthermore, two-way ANOVA analysis (P=0.02) revealed that the reduced BV/TV at the trabecular site in the pOVX group is due to partial estrogen loss when compared to sham mice, validating the proposed model for further study.

Gene expression profile, insulin content and glucose dependent secretion, normalization of glycemia upon transplantation into diabetic mice validated the approach to generate beta cell lines.

The achievement of Vp16-Jazz transgenic mice validates the strategy of transcriptional targeting of endogenous genes and could represent an exclusive animal model for use in drug discovery and therapeutics.

The hypotensive phenotype of the SPAKL502A/L502A mice validate the CCT domain as a promising new target for future anti-hypertensive agents.

These mice validate the idea that the recurrent activating mutation of the BMP type I receptor ACVR1 (R206H) occurring in all individuals with classic clinical features of the disease (Shore et al., 2006) is the direct genetic cause of FOP and of all of its resulting pathology (Chakkalakal et al., 2012).

We have recently generated Cbx7-KO mice validating a tumor suppressor role of the Cbx7 gene since these mice developed liver and lung adenomas and carcinomas that were associated with an increased expression of the cyclin E gene.

In our study, we examined the nigrostriatal DA pathway in Wnt5a−/− mice, validating a number of our in vitro findings and the importance of Wnt5a in DA connectivity.