Sentence examples for mice using pharmacological from inspiring English sources

Finally, we asked whether we could restore pattern completion in these DAT+/− mice using pharmacological methods.

Future studies in mice using pharmacological inhibitors to suppress NF-κB activation (e.g. salicylates that inhibit IKKβ (49) or treatment with adiponectin to block TLR pathways) will shed light on whether the early proinflammatory phase of X-ALD is neuroprotective or, in the contrary, contributes to axonopathy.

We next investigated the role of NF-κB signalling in C.jejuni induced host response in BMDC generated from WT mice using the pharmacological inhibitor Bay 11-7085.

Relevance of CXCR7/CXCR7 ligands for CRC metastasis was then investigated in mice using small pharmacological CXCR7 antagonists and CRC cell lines of human and murine origins, which – injected into mice – enable the development of lung and liver metastases.

The paper by Cook et al. tackled the challenging topic of elucidating the mechanistic basis of dilated cardiomyopathy (DCM) in Marfan syndrome mice, using genetic, pharmacological and embryological manipulations.

Supporting the relevance of this approach, it was shown that inhibition of Hif1 in mice using either pharmacological inhibition or conditional gene deletion significantly reduces airway inflammation in models of asthma [ 24, 25].

17, 18 We thus investigated the social recognition/memory in the Thy1-APPLond/Swe (APP) mouse model of AD using pharmacological and molecular tools and showed the social recognition deficit observed in APP mice is associated with abnormalities in β1-ADR signaling in the medial amygdala (MeA).

These results are consistent with previous observations from our laboratory using pharmacological inhibitor or heterozygous mice for PARP-1 on C57BL/6 genetic background[15] and findings from von Lukowicz et al [18] using PARP-1−/− mice on a mixed genetic background.

Using pharmacological inhibition, overexpression, and transgenic mouse models, we demonstrate that Akt negatively regulates Fas expression.

Consistent with the data using pharmacological inhibitors, EPC derived from PKC delta +/− mice exhibited a reduced capacity to differentiate to CMs upon co-culture with neonatal CMs.

Our previous results [ 8] wherein we have used SP precursor knockout mice demonstrated complete reversal of manifestations of murine viral-myocarditis, whereas our current studies using pharmacological inhibition showed reduction, although significant but not complete prevention of the manifestations.