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About the same time, researchers at the University of Toronto, inspired by discussions with Dr. Folkman, were doing similar studies in mice, using low doses of a chemotherapy drug, vinblastine, combined with an experimental drug that fights angiogenesis, DC101.
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In experiments in Swiss mice using low-level lead exposures similar to and lower than those used by Giddabasappa et al. (2011), we observed an increase in the number of red blood cells, in female gestational parameters, and in Th1 cytokine levels (Iavicoli et al. 2003, 2004, 2006a, 2006b).
Exercised mice were trained using low intensity daily exercise for five weeks.
Cyanine-labelled cRNA (Perkin Elmer Life Sciences, Waltham, Massachusetts) was produced from individual liver samples (2 µg) from 40 mice (two time points, comprised of 4 treatment groups with 5 mice each) and URR using Low RNA Input Fluorescent Amplification kits (Agilent Technologies) according to the manufacturer's instructions.
Treatments were beneficial even in adult and old MPSII mice, using relatively low doses of infused IDS over long intervals.
Nonetheless, the first evaluations of morphologic and functional alterations of infected mouse hearts were performed using low frequency probes in clinical grade ultrasound equipment and suggested a decrease of left ventricular fractional shortening in chronically infected animals [ 22].
An increased rate of endochondral ossification was demonstrated in mouse metatarsal rudiments using low-intensity ultrasound [ 5].
The mouse open wound infection model [28] was used to determine P. aeruginosa (Xen5) cell proliferation over time, via in vivo serial imaging of bacterial bioluminescence in live mice using a Hamamatsu low light camera.
We induced CAC in mice using a single low dose of AOM followed by a single week of treatment with DSS (30, 39).
We previously compared MAE between mouse and human immortalized lymphoid cells using low-resolution maps; 29 orthologous gene pairs could be assessed, nevertheless showing significant MAE conservation (Zwemer et al. 2012).
When he lit the dinosaur wing of the American Museum of Natural History, he used low lights to appeal to kids, "running through the bones like electric mice".
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