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These circumstances allowed the performance of more detailed imaging studies with tumor-bearing mice using in vivo PET/CT.

Temporal and spatial profiles of O2 · − after permanent focal ischemia have been examined in mice using in situ staining with dihydroethidium (DHE) [23].

The present study was designed to investigate the effects of acute and chronic administration of MK-801 (0.6 mg/kg), a noncompetitive NMDA-receptor antagonist on extracellular glutamate (Glu) and ascorbic acid (AA) release in the prefrontal cortex (PFC) of freely moving mice using in vivo microdialysis with open-field behavior.

We have recently shown that transgenic rodent parasites expressing luciferase are useful reagents to determine parasite load and bio-distribution of blood stages in live mice using in vivo imaging [36], [37].

To further study the role of Jak3 in CCR7-dependent DC migration, we analyzed the migration capacity of mature BMDCs (mBMDCs) derived from Jak3−/− and Jak3+/+ mice using in vitro chemotaxis assays.

Reasoning that the rate of cell loss must be balanced by the rate of cell renewal to avoid organ failure and ultimately death, at a much earlier age than actually observed, we subsequently evaluated cell proliferative responses in the liver of these mice using in situ Ki-67 immunostaining.

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In another study of the biodistribution in PC-bearing mice using In-DOTA-AMBA the mice were killed 1 h after injection only, and sufficient tumour uptake was shown [ 36].

The recipient mice used in the competitive transplantation assays were either CD45.1 mice or CD45.1/CD45.2 mice.

All mice used in the studies were approved by the Animal Care Committee, Queen's University.

The mice used in the experiment were all C57BL/6, respectively purchased from Shanghai SLAC Laboratory Animal Co., Ltd. and Beijing Vital River Laboratory Animal Technology Co., Ltd.

The APPswe-PS1dE9 male mice used in ex vivo studies were a kind gift from Professor H. Tanila from the University of Eastern Finland.

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