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GeneRaVE [24] identified several sets of genes that could be used to discriminate the different strains of mice under study.
Histopathological analysis of TRF2 Δ/Δ -K5-Cre, TRF2 Δ/Δ -K5-Cre 53BP1 −/− and TRF2 Δ/Δ -K5-Cre p53 −/− neonates revealed that the overall clinical picture was equally severe in the single knockout as in the compound mice under study (Fig 4).
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We found that the mouse strains under study do not only display moderate variations in their intraocular pressure, retinal architecture, and retinal ganglion cell density, also the retinofugal projections to the dorsal lateral geniculate nucleus and the superior colliculus revealed striking differences, potentially underlying diverging optokinetic tracking responses and visual acuity.
This difference may reflect differences between the two mouse mammary systems under study.
For human immune cell types, a gene expression dataset was compiled from different public sources as previously described [ 29], in order to include all the cell types known or proposed to be homolog to the mouse cell types under study, namely CD141+ cDC, CD1c+ cDC, pDC, B cells, NK cells and CD8+ T cells, as well as neutrophils as a negative control.
Goblet cells were stained with alcian blue on slides from the small intestine of mice from different groups under study and the results were expressed as number of positive cells per 10 villi.
A new approach to image fixed biological samples by expanding the specimen under study reveals mouse brain substructures.
Separately, wild-type mouse plasma containing the polymer under study (prepared as for the aPTT assay) was warmed to 37 °C.
In our microarray analysis, we found that different elements of the TLR pathway were dysregulated in our mouse model at all ages under study.
We searched the available genome sequences of house mice, including those of the populations under study, for possible inserts that could be the direct source of the P-MLV transcripts that we detected in the feces.
These findings agree well with atropine effects on spontaneous behavioral arrests in orexin ligand KO mice studied under a food shift paradigm (Willie, 2005).
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