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1) Fgf10 +/- mice under normoxic condition have worse lung function and lung structure compared to WT mice.
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Baseline ventilation was recorded for 60 min while the mice breathed under normoxic conditions.
None of these histological alterations were seen in TH-VHLKO mice living under normoxic conditions (Supplementary Fig S6A C).
Strikingly, application of an IPAS antisense oligonucleotide to the mouse cornea induced angiogenesis under normoxic conditions, and unmasked hypoxia-dependent induction of VEGF gene expression in hypoxic cornea cells.
When maintained under normoxic conditions, TH-VHLKO mice show full development of the brain and other organs and normal physiological functions.
In addition, CHL1−/− mice had higher blood pressure and plasma catecholamine levels under normoxic conditions, indicative of a greater sympathetic tone, compared with wild-type mice.
A recent report showed a small change (<9%) in skin oxygenation of mice after one hour of administration of ketamine anesthesia under normoxic conditions [ 30].
Baseline (e.g. no induced flow alteration) pO2 gradients in descending arterioles under normoxic conditions are presented in two mice (Fig. 3 ).
Literature documents that diabetic mice fibroblasts show a severe impairment in VEGF production under normoxic and hypoxic conditions in addition to an increased pro-degradative activity due to the high expression of matrix metalloprotease type 9 (MMP-9) [ 28].
However, these mice also exhibited increased RV systolic pressures and increased pulmonary artery muscularization under normoxic conditions.
A perfluorotributylamine (PFTBA) emulsion was co-encapsulated at 10 vol% with mouse βTC-tet insulinoma cells in calcium alginate beads and cultured under normoxic and severely hypoxic conditions.
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