We examined T cell trafficking in FtDKO mice under non-inflammatory conditions, as well as following inflammation due to viral infection.
To determine whether naïve or memory CD8 T cells, capable of expressing selectin ligands, selectively homed to the lung of FtDKO mice, we performed adoptive transfer of bona fide P14.Tg WT naïve and central memory CD8 T cells into WT or FtDKO recipient mice under non-inflammatory conditions.
The present study analyzed Nod1 and Nod2 double deficient (Nod1/2 DKO) mice under physiological and inflammatory conditions.
IL-17A does not play a role in physiological bone remodelling as shown by our IL-17A-/--deficient mice studies; however, IL-17A is secreted by Th17 cells under inflammatory conditions.
Similarly, the generation of iTreg was strongly diminished when NFATc1/c2-double deficient T cells – instead of wild type T cells - were co-transferred into lymphopenic mice to induce colitis (which is an approach to induce iTreg under inflammatory conditions [ 71]).
Then, in order to analyze beneficial effects of EcN under inflammatory conditions, the probiotic was orally administered to BALB/c mice with acute dextran sodium sulfate (DSS) induced colitis.
To decipher the significance of platelet monocyte associations under inflammatory or infectious conditions, thioglycollate-induced peritonitis model in mice was utilized.
Therefore, the expression of iNOS under inflammatory conditions is critical for MSC-induced therapeutic effects on mouse liver fibrosis.
For example, lineage-tracing experiments have shown that under inflammatory conditions it is possible to find in the pancreas of NOD mice a population of ex-Treg that, though once positive for FOXP3 have become FOXP3− 39.
In mice, Gr1+CX3CR1low Mo (homolog of human CD16- Mo) are recruited into the peritoneal cavity or draining lymph nodes under inflammatory conditions by mechanisms dependent on CCR2 and CD62L, and subsequently differentiate into DC [ 19, 31- 33].
