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No study had previously investigated sympathetic system related parameters in the adipose tissue of mice under chronic stress.
Overall, our data indicate that subordinate male mice under chronic stress represent a valid model of stress-induced depression-related disorders [15], [16].
This analysis revealed that dominant mice under chronic stress showed a clear adipocytes remodeling thus suggesting that the reduction in body weight may be due to sympathetic-driven lipolysis leading to overall reduction of adipocytes size and adipose tissue weight.
These findings, in addition to increased NE concentration in the same fat pad, suggests that a sympathetic mediated lipolysis is the primary cause of the reduction of fat mass in dominant mice under chronic stress.
Note that we examined gene expression in all mice under chronic stress conditions.
In this study, we found that mice under chronic cold restraint stress contained high level of MDA with depletion of SOD level (Table 2).
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However, the nature of the remodeling differs between species, and it has been shown that mice kept under chronic hypoxia develop less PH than do rats maintained under comparable conditions [ 13].
In our mice model under chronic CCl4 administration, increased hepatocyte apoptosis and reduced antiapoptotic protein Bcl-2 expression as well as enhanced expression of proapoptotic protein Bax and activation of caspase-3 were observed in livers of PP2Ac α knockdown mice.
In conclusion, cognitive performances of adult mouse lemurs under chronic CR are maintained or improved in the case of executive functions.
In our mouse model under chronic CCl4 administration, hepatocyte apoptosis was suppressed with increased anti-apoptotic protein bcl-2 and HGF expression in the livers by hAMCs transplantation.
M6a mRNA was found to be upregulated in the hippocampus of both mice and tree shrews under chronic stress [58], [59].
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