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We did not notice any change in serum corticosterone levels in Gpr3−/− mice under basal conditions or in response to the stress induced by the tail suspension test.
In keeping with this proposal, our data permit to explain the observation of a defective mitochondrial respiration found in muscle strips but not in isolated mitochondria from PGC-1β KO mice under basal conditions [20].
Avp mRNA expression in the PVN of male LAB, F1 and HAB mice under basal conditions is significantly correlated with anxiety-related behavior (r = 0.619; p<0.001; Fig. 7A) as well as depression-like behavior (r = 0.655; p<0.001; Fig. 7B).
As seen in Fig 7, VELF was near zero in both groups of mice under basal condition (no infusion).
D2R KO mice spent significantly less time immobile than WT mice under basal conditions = 3.425, p < 0.01).
We measured serum levels of corticosterone in Wfs1/CKO and control mice under basal conditions and after 30 min of ARS.
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In keeping with these data, this reduction in mitochondrial size is absent in PGC-1α KO mouse under basal conditions, probably due to normal PGC-1β expression [21], [24].
FGF21-null mice kept under basal conditions exhibited increased lipid content, indicative of impaired activity and 'whitening' of BAT (Fig. 9b).
Overall stress removed the affective behavioral differences between UCN3OE and control mice seen under basal conditions.
However, the levels of autophosphorylated (active) CaMKII were increased in CM GC-A KO mice already under basal conditions (vehicle treatment; Fig. 6a, b).
The livers of these mice, even under basal conditions, displayed massive accumulation of lipid droplets and abnormally high levels of intracellular cholesterol and triglyceride.
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